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Several research groups have hypothesized that chronic inflammation is a key regulator in the development of lymphedema. Th cells, particularly Th2 differentiation, play a crucial role in the pathophysiology of lymphedema. Research has shown that increased expression of Th2-inducing cytokines in the epidermal cells of the lymphoedematous limb.
Neil "George" Piller is an Australian professor of lymphology at the Department of Surgery, School of Medicine, Flinders University. Piller is also the Director of the Lymphoedema Assessment Unit, Flinders Surgical Oncology as well as member of the Flinders University microcirculatory and lymphological research group. [1]
The pathophysiology is not yet well understood. Leukocytoclastic vasculitis is proposed to be the underlying cause resulting in reactive lymphedema. [2] Prolonged standing with full knee extension and minimal movement for a prolonged period of time is postulated to induce a temporary failure in pumping the venous and lymphatic systems in the calf region leading to acute gravity-dependent ...
Proponents state it can be used for lymphedema [1] and breast cancer. [2] ... Research Council for Complementary Medicine. Archived from the original on 21 April 2010.
Studies show mixed results regarding the efficacy of the method in treating lymphedema, and further studies are needed. [3] A 2013 systematic review of manual lymphatic drainage with regard to breast cancer –related lymphedema found no clear support for the effectiveness of the intervention in either preventing limb edema in at-risk women or ...
Lymphedema most commonly arises in the arms or legs, but can also occur in the chest wall, genitals, neck, and abdomen. [35] Secondary lymphedema usually results from the removal of lymph nodes during breast cancer surgery or from other damaging treatments such as radiation. It can also be caused by some parasitic infections.
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