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Awareness of lymphedema -- excessive, debilitating swelling related to lymph node blockage -- is growing, particularly as it affects women after breast cancer treatment. Treatments like surgery ...
Several research groups have hypothesized that chronic inflammation is a key regulator in the development of lymphedema. Th cells, particularly Th2 differentiation, play a crucial role in the pathophysiology of lymphedema. Research has shown that increased expression of Th2-inducing cytokines in the epidermal cells of the lymphoedematous limb.
Secondary lymphedema is a condition characterized by swelling of the soft tissues in which an excessive amount of lymph has accumulated, and is caused by certain malignant diseases such as Hodgkin's disease and Kaposi sarcoma. [1]: 849
Lymphedema. Lymphedema is the chronic pooling of lymph fluid in the tissue. Lymphedema can start anywhere in the lymphatic system of the body. It's also a side-effect of some surgical procedures. Kathy Bates is an advocate and supporter for further research for lymphedema. [3] Lymphocytosis. Lymphocytosis is a high lymphocyte count.
The concept of the sentinel lymph node is important because of the advent of the sentinel lymph node biopsy technique, also known as a sentinel node procedure.This technique is used in the staging of certain types of cancer to see if they have spread to any lymph nodes, since lymph node metastasis is one of the most important prognostic signs.
Angiosarcoma is found to occur in 0.07% to 0.45% of people who survive at least 5 years after a radical mastectomy.Although the majority of Stewart-Treves syndrome-related angiosarcomas are caused by post-mastectomy lymphedema, angiosarcoma development has been linked to persistent lymphedema of any origin.
Lymphangiosarcoma is a rare cancer which occurs in long-standing cases of primary or secondary lymphedema (swelling due to lymphatic system obstruction). It involves either the upper or lower lymphedematous extremities but is most common in upper extremities. [1]
An experimental nasal spray has helped clear toxic protein buildups in the brains of mouse models of Alzheimer's. Its developers believe the spray may help delay Alzheimer's by at least a decade.