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Top: An ancestral gene duplication produces two paralogs (histone H1.1 and 1.2). A speciation event produces orthologs in the two daughter species (human and chimpanzee). Bottom: in a separate species , a gene has a similar function (histone-like nucleoid-structuring protein) but has a separate evolutionary origin and so is an analog.
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]
Homology was noticed by Aristotle (c. 350 BC), [1] and was explicitly analysed by Pierre Belon in his 1555 Book of Birds, where he systematically compared the skeletons of birds and humans. The pattern of similarity was interpreted as part of the static great chain of being through the mediaeval and early modern periods: it was not then seen as ...
5883 19367 Ensembl ENSG00000172613 ENSMUSG00000024824 UniProt Q99638 Q9Z0F6 RefSeq (mRNA) NM_001243224 NM_004584 NM_011237 RefSeq (protein) NP_001230153 NP_004575 NP_035367 Location (UCSC) Chr 11: 67.32 – 67.4 Mb Chr 19: 4.25 – 4.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene ...
In Hyphomicrobiales and Enterobacteriales, syntenic genes encode a large number of essential cell functions and represent a high level of functional relationships. [ 15 ] Patterns of shared synteny or synteny breaks can also be used as characters to infer the phylogenetic relationships among several species, and even to infer the genome ...
HomoloGene, a tool of the United States National Center for Biotechnology Information (NCBI), is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes.
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The paralogs of EVA1C are EVA1A (Eva-1 Homolog A) and EVA1B (Eva-1 Homolog B). [17] [18] The thorny skate (Amblyraja radiata) was found to be the most distant ortholog in EVA1A, EVA1B, and EVA1C. [14] [19] [20] The divergence time of humans and the thorny skate is 464 million years ago. [16]