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A common synthesis for porphyrins is the Rothemund reaction, first reported in 1936, [12] [13] which is also the basis for more recent methods described by Adler and Longo. [14] The general scheme is a condensation and oxidation process starting with pyrrole and an aldehyde .
Pages in category "Porphyrins" The following 15 pages are in this category, out of 15 total. This list may not reflect recent changes. ...
Porphyria / p ɔːr ˈ f ɪr i ə / is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. [1] The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and short in duration. [1]
The porphyrin with a core phosphorus (V) ion can be tuned with additional substituents added to either the outside of the polycyclic ring system or axially to the core phosphorus. Meso-substituted porphyrins like meso-tetra-p-tolylporphyrin (TTP) and octaethylporphyrin (OEP) are often used in synthesis of the core phosphorus porphyrin.
The general term protoporphyrin refers to porphine derivatives that have the outer hydrogen atoms in the four pyrrole rings replaced by other functional groups. The prefix proto often means 'first' in science nomenclature (such as carbon protoxide), hence Hans Fischer is thought to have coined the name protoporphyrin as the first class of porphyrins. [3]
This is the most common form. In the synthesis of porphyrin , it is created from the linear tetrapyrrole hydroxymethylbilane by the enzyme uroporphyrinogen III synthase , and is further converted into coproporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase .
Variegate porphyria, also known by several other names, is an autosomal dominant porphyria [3] that can have acute (severe but usually not long-lasting) symptoms along with symptoms that affect the skin. The disorder results from low levels of the enzyme responsible for the seventh step in heme production.
Boron porphyrins are a variety of porphyrin, a common macrocycle used for photosensitization and metal trapping applications, that incorporate boron. The central four nitrogen atoms in a porphyrin macrocycle form a unique molecular pocket which is known to accommodate transition metals of various sizes and oxidation states .