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Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. [18] It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous and subcutaneous), as a skin patch (transdermal), or as an implant.
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
The International Committee for Weights and Measures states: "In order to avoid any risk of confusion between the absorbed dose D and the dose equivalent H, the special names for the respective units should be used, that is, the name gray should be used instead of joules per kilogram for the unit of absorbed dose D and the name sievert instead ...
Recognized effects of higher acute radiation doses are described in more detail in the article on radiation poisoning.Although the International System of Units (SI) defines the sievert (Sv) as the unit of radiation dose equivalent, chronic radiation levels and standards are still often given in units of millirems (mrem), where 1 mrem equals 1/1,000 of a rem and 1 rem equals 0.01 Sv.
English: Radiation Dose Chart by Randall Munroe as part of the webcomic xkcd (SVG version of ). In response to concerns about the radioactivity released by the Fukushima Daiichi nuclear disaster:Fukushima Daiichi nuclear disaster in 2011, and to remedy what he described as "confusing" reporting on radiation levels in the media, Munroe created a chart of comparative radiation exposure levels.
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The deterministic effects that can lead to acute radiation syndrome only occur in the case of high doses (> ~10 rad or > 0.1 Gy) and high dose rates (> ~10 rad/h or > 0.1 Gy/h). A model of deterministic risk would require different weighting factors (not yet established) than are used in the calculation of equivalent and effective dose.