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Cluster headache is a neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye(s). [1] There is often accompanying eye watering, nasal congestion, or swelling around the eye on the affected side. [1]
The three most common types are tension headaches, migraines and cluster headaches, according to Cohen. "Tension headaches are among the most frequent types and are what most people consider a ...
The drugs of this class act as agonists for serotonin 5-HT 1B and 5-HT 1D receptors at blood vessels and nerve endings in the brain. The first clinically available triptan was sumatriptan, which has been marketed since 1991. Triptans have largely replaced ergotamines, an older class of medications used to relieve migraine and cluster headaches. [3]
Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. [1] It is taken orally, intranasally, or by subcutaneous injection. [2] Therapeutic effects generally occur within three hours. [2]
Trigeminal autonomic cephalalgia (TAC) refers to a group of primary headaches that occurs with pain on one side of the head in the trigeminal nerve area and symptoms in autonomic systems on the same side, such as eye watering and redness or drooping eyelids. [1] [2]
Lilly's (LLY) CGRP antibody, Emgality, becomes the first and only medicine approved to treat episodic cluster headache in adults.
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