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Symptoms start two hours to five days after exposure. [3] Cholera is caused by a number of types of Vibrio cholerae, with some types producing more severe disease than others. [2] It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. [2] Undercooked shellfish is a common source. [9]
Although Koch was convinced that the bacterium was the cholera pathogen, he could not entirely procure critical evidence that the bacterium produced the symptoms in healthy subjects (an important element in what was later known as Koch's postulates). His experiment on animals using his pure bacteria culture did not lead to the appearance of the ...
Descriptions of cholera are found as early as the 5th century BC in Sanskrit. [4] The study of cholera in England by John Snow, between 1849 and 1854, led to significant advances in the field of epidemiology. [4] [10] Seven large outbreaks have occurred over the last 200 years, with millions of deaths. [11]
Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is an AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. [ 1 ] [ 2 ] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. [ 3 ]
Symptoms of the disease appear between 12 hours and 5 days of infection; however, only 10% of infected people show severe symptoms of watery diarrhoea, vomiting and leg cramps. [8] Cholera is diagnosed through a stool test or rectal swab, and today treatment takes the form of an oral rehydration solution (ORS).
Dozens of escaped residents of the besieged town of al-Hilaliya in Sudan's El Gezira state have tested positive for cholera, a medical source told Reuters, in a development that provides a likely ...
The oral cholera vaccine, while effective for cholera, is of questionable use for travelers' diarrhea. [6] Preventive antibiotics are generally discouraged. [ 3 ] Primary treatment includes rehydration and replacing lost salts ( oral rehydration therapy ).
These days, Catherine Mangosho locks her 3-year-old grandson in the house for hours on end in an attempt to shield him from a deadly cholera outbreak in Zimbabwe. The virulent bacterial disease is ...