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All SOCS have certain structures in common. This includes a varying N-terminal domain involved in protein-protein interactions, a central SH2 domain, which can bind to molecules that have been phosphorylated by tyrosine kinases, and a SOCS box located at the C-terminal that enables recruitment of E3 ligases and ubiquitin signaling molecules. [1]
56468 Ensembl ENSG00000171150 ENSMUSG00000037104 UniProt O75159 O54928 RefSeq (mRNA) NM_144949 NM_014011 NM_019654 RefSeq (protein) NP_054730 NP_659198 NP_062628 Location (UCSC) Chr 2: 46.7 – 46.78 Mb Chr 17: 87.42 – 87.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene. The protein ...
Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. [ 5 ] [ 6 ] [ 7 ] This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family.
Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. [ 5 ] [ 6 ] This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling ( SOCS ), family.
The SH2 domain is formed of 2 α-helices and a β-sheet and is formed approximately from residues 575–680. [2] [3] STATs also have transcriptional activation domains (TAD), which are less conserved and are located at the C-terminus. [4] In addition, STATs also contain: tyrosine activation, amino-terminal, linker, coiled-coil and DNA-binding ...
Image credits: BallinFC #10. The Candy Bomber. After World War II, when Berlin was divided, the US and UK airlifted supplies into West Berlin to counter the Soviet blockade.
An Act to make further Provision respecting certain Payments to and from the Bank of England, and to increase the Facilities for the Transfer of Stocks and Annuities, and for other Purposes. (Repealed by Government Stock (Consequential and Transitional Provision) (No. 2) Order 2004 )
Separation of concerns is an important design principle in many other areas as well, such as urban planning, architecture and information design. [5] The goal is to more effectively understand, design, and manage complex interdependent systems, so that functions can be reused, optimized independently of other functions, and insulated from the ...