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The subthalamic nucleus (STN) is a small lens-shaped nucleus in the brain where it is, from a functional point of view, part of the basal ganglia system. In terms of anatomy, it is the major part of the subthalamus. As suggested by its name, the subthalamic nucleus is located ventral to the thalamus.
The subthalamic nucleus, whose neurons contain glutamate and have excitatory effects over neurons of globus pallidus and substantia nigra Zona incerta , located between fields of Forel H 1 and H 2 . It is continuous with the thalamic reticular nucleus and receives input from the precentral cortex .
The subthalamic nucleus is a diencephalic gray matter portion of the basal ganglia, and the only portion of the ganglia that produces an excitatory neurotransmitter, glutamate. The role of the subthalamic nucleus is to stimulate the SNr-GPi complex and it is part of the indirect pathway. The subthalamic nucleus receives inhibitory input from ...
The direct pathway passes through the caudate nucleus, putamen, and globus pallidus, which are parts of the basal ganglia.It also involves another basal ganglia component the substantia nigra, a part of the midbrain. [2]
The subthalamic nucleus gives excitatory input that modulates the rate of firing of these spontaneous action potentials. However, lesion of the subthalamic nucleus leads to only a 20% decrease in pars reticulata firing rate, suggesting that the generation of action potentials in the pars reticulata is largely autonomous, [ 13 ] as exemplified ...
GPe neurons are often multi-targeted and may respond to a number of neuron types. In macaques, axons from the GPe to the striatum account for about 15%; those to the GPi, SNpr and subthalamic nucleus are about 84%. The subthalamic nucleus was seen to be the preferred target which also sends most of its axons to the GPe. [24]
The vestibulospinal tract is an upper motor neuron tract consisting of two sub-pathways: The medial vestibulospinal tract projects bilaterally from the medial vestibular nucleus within the medial longitudinal fasciculus to the ventral horns in the upper cervical cord (C6 vertebra). [5]
The zona incerta (ZI) is a horizontally elongated small nucleus that separates the larger subthalamic nucleus from the thalamus. [1] Its connections project extensively over the brain from the cerebral cortex down into the spinal cord.