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Troponin I is a biomarker that responds to treatment interventions. Reductions in troponin I levels proved to reduce the risk of future CVD. [23] [24] [25] High sensitive troponin I used as a screening tool to assess a person's cardiovascular risk and has the potential to reduce the growing cost burden of the healthcare system. [26]
Test Sensitivity and specificity Approximate peak Description Troponin test: The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is composed of 3 proteins- Troponin C, Cardic troponin I, and Cardiac troponin T. Troponin I especially has a high affinity for myocardial injury.
Strenuous endurance exercise such as marathons or triathlons can lead to increased troponin levels in up to one-third of subjects, but it is not linked to adverse health effects in these competitors. [27] [28] [29] High troponin T levels have also been reported in patients with inflammatory muscle diseases such as polymyositis or dermatomyositis.
Cardiac troponin T (low sensitive) 0.1 [7] ng/mL: 99th percentile cutoff: Cardiac troponin I (high sensitive) 0.03 [7] ng/mL 99th percentile cutoff: Cardiac troponin T (high sensitive) Male 0.022 [7] ng/mL 99th percentile cutoff: Female 0.014 [7] ng/mL 99th percentile cutoff: newborn/infants not established more than adults [60] [61]
7135 21952 Ensembl ENSG00000159173 ENSMUSG00000026418 UniProt P19237 Q9WUZ5 RefSeq (mRNA) NM_003281 NM_001112702 NM_021467 RefSeq (protein) NP_003272 NP_001106173 NP_067442 Location (UCSC) Chr 1: 201.4 – 201.43 Mb Chr 1: 135.71 – 135.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene. It is ...
Troponin levels increase in 35-50% of people with pericarditis. [ 8 ] Electrocardiogram (ECG) changes in acute pericarditis mainly indicates inflammation of the epicardium (the layer directly surrounding the heart), since the fibrous pericardium is electrically inert.
Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene. [ 5 ] [ 6 ] It is a tissue-specific subtype of troponin I , which in turn is a part of the troponin complex . The TNNI3 gene encoding cardiac troponin I (cTnI) is located at 19q13.4 in the human chromosomal genome.
A rise in troponin occurs within 2–3 hours of injury to the heart muscle, and peaks within 1–2 days. The level of the troponin, as well as a change over time, are useful in measuring and diagnosing or excluding myocardial infarctions, and the diagnostic accuracy of troponin testing is improving over time. [72]