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Liver failure; Pancreatitis (these two usually occur in first 6 months and can be fatal); Leukopenia (low white blood cell count); Neutropenia (low neutrophil count); Pure red cell aplasia
Common side effects of valproate include nausea, vomiting, somnolence, and dry mouth. [7] Serious side effects can include liver failure, and regular monitoring of liver function tests is therefore recommended. [7] Other serious risks include pancreatitis and an increased suicide risk. [7]
Adverse effects by frequency for use of valproate semisodium. [1] [2] [3] Very common (>10% frequency) Nausea; Tremor;
The valproates — valproic acid, sodium valproate, and divalproex sodium (1967). Vigabatrin (1989). ... The newer drugs tend to have fewer side effects. [42]
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Fetal valproate spectrum disorder (FVSD), previously known as fetal valproate syndrome (FVS), is a rare disease caused by prenatal exposure to valproic acid (VPA), a medication commonly used to treat epilepsy, bipolar disorder, and migraines.
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In addition, lamotrigine shares few side effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasizes its unique properties. [72] It is a triazine derivate that inhibits voltage-sensitive sodium channels, leading to stabilization of neuronal membranes.
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