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In 1997, the United States Food and Drug Administration approved difloxacin hydrochloride tablets for use in canines. [5] [6] Unlike other fluoroquinolones difloxacin has not been approved by the FDA for use in cats. It is also contraindicated for use in food animals. [2] The recommended dosing is 5–10 mg/kg once daily.
[1] [2] It contains medetomidine, an alpha2-adrenoceptor agonist, as the hydrochloride; and vatinoxan, an alpha2-adrenoceptor antagonist, as the hydrochloride. [ 2 ] [ 3 ] It was approved for veterinary use in the United States in May 2022, [ 2 ] and in Canada in May 2023.
Atipamezole has also been used as an antidote for various toxicities in dogs. For example, the anti- tick medication amitraz is commonly ingested by dogs who eat their anti-tick collars . [ 19 ] Amitraz works by the same mechanism as dexmedetomidine and is thus easily reversed by atipamezole.
Related: Benadryl for Dogs: Side Effects of Long-Term Use. Signs of Benadryl Overdose in Dogs. At normal doses, Benadryl is quite safe, but a survey of over 600 dogs (1) found the following signs ...
Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation. [4] Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses. [10] [11] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder. [5]
Enrofloxacin, sold under the brand name Baytril, among others, is a fluoroquinolone antibiotic used for the treatment of animals. [1] It is a bactericidal agent. [1]The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure.