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A cyclin-dependent kinase inhibitor (CKI) is a protein that interacts with a cyclin-CDK complex to inhibit kinase activity, often during G1 phase or in response to external signals or DNA damage. In animal cells, two primary CKI families exist: the INK4family (p16, p15, p18, p19) and the CIP/KIPfamily (p21, p27, p57).
Kernel density estimation of 100 normally distributed random numbers using different smoothing bandwidths.. In statistics, kernel density estimation (KDE) is the application of kernel smoothing for probability density estimation, i.e., a non-parametric method to estimate the probability density function of a random variable based on kernels as weights.
A kinetochore (/ kɪˈnɛtəkɔːr /, /- ˈniːtəkɔːr /) is a disc-shaped protein structure associated with duplicated chromatids in eukaryotic cells where the spindle fibers attach during cell division to pull sister chromatids apart. [ 1 ] The kinetochore assembles on the centromere and links the chromosome to microtubule polymers from the ...
An actogram is a plot that shows rhythms in biological variables throughout the day. Traditionally, actograms describe phases of activity and rest, but they have also been used to visualize rhythms in protein phosphorylation, gene expression, and hormone secretion.
[4] Pearson himself noted in 1895 that although the term "histogram" was new, the type of graph it designates was "a common form of graphical representation". [ 5 ] In fact the technique of using a bar graph to represent statistical measurements was devised by the Scottish economist , William Playfair , in his Commercial and political atlas (1786).
In biology, a biological life cycle (or just life cycle when the biological context is clear) is a series of stages of the life of an organism, that begins as a zygote, often in an egg, and concludes as an adult that reproduces, producing an offspring in the form of a new zygote which then itself goes through the same series of stages, the ...
A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions that occur within a biological cell when initiated by a stimulus. This stimulus, known as a first messenger, acts on a receptor that is transduced to the cell interior through second messengers which amplify the signal and transfer ...
Cell cycle checkpoints are control mechanisms in the eukaryotic cell cycle which ensure its proper progression. Each checkpoint serves as a potential termination point along the cell cycle, during which the conditions of the cell are assessed, with progression through the various phases of the cell cycle occurring only when favorable conditions ...