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  2. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]

  3. Clark's rule - Wikipedia

    en.wikipedia.org/wiki/Clark's_rule

    The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.

  4. Clearance (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Clearance_(pharmacology)

    Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and excretion of a substance are related, they are not the same thing.

  5. Volume of distribution - Wikipedia

    en.wikipedia.org/wiki/Volume_of_distribution

    An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...

  6. Loading dose - Wikipedia

    en.wikipedia.org/wiki/Loading_dose

    That immediately gets the drug's concentration in the body up to the therapeutically-useful level. First day: 1000 mg; the body clears 100 mg, leaving 900 mg. On the second day, the patient takes 100 mg, bringing the level back to 1000 mg; the body clears 100 mg overnight, still leaving 900 mg, and so forth.

  7. International unit - Wikipedia

    en.wikipedia.org/wiki/International_unit

    Multivitamins nutrition facts label showing that the international unit of, for example, vitamins D and E correspond to different gram values. In pharmacology, the international unit (IU) is a unit of measurement for the effect or biological activity of a substance, for the purpose of easier comparison across similar forms of substances.

  8. Effective dose (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Effective_dose_(pharmacology)

    The ED50 is commonly used as a measure of the reasonable expectancy of a drug effect, but does not necessarily represent the dose that a clinician might use. This depends on the need for the effect, and also the toxicity. The toxicity and even the lethality of a drug can be quantified by the TD 50 and LD 50 respectively. Ideally, the effective ...

  9. Equivalent (chemistry) - Wikipedia

    en.wikipedia.org/wiki/Equivalent_(chemistry)

    20*39.098/1=782 mg Potassium citrate monohydrate C 6 H 7 K 3 O 8: 324.41 g/mol 3 (K +) Liquid potassium citrate/gluconate therapy for adults and teenagers taken two to four times a day [3] 20 mEq potassium 20*324/3=2160 mg Potassium gluconate (anhydrous) C 6 H 11 KO 7: 234.245 g/mol 1 (K +)