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Myristic acid (IUPAC name: tetradecanoic acid) is a common saturated fatty acid with the molecular formula CH 3 (CH 2) 12 COOH. Its salts and esters are commonly referred to as myristates or tetradecanoates. The name of the acyl group derived from myristic acid is myristoyl or tetradecanoyl.
N-myristoyltransferase inhibitors are small molecules that target and inhibit N-myristoyltransferases, which block the addition of myristic acid to the penultimate glycine of proteins with myristoylation signal. The prototype is the DDD85646, [1] and the analogues IMP-1088 and zelenirstat (PCLX-001).
Myristoylation is a lipidation modification where a myristoyl group, derived from myristic acid, is covalently attached by an amide bond to the alpha-amino group of an N-terminal glycine residue. [1] Myristic acid is a 14-carbon saturated fatty acid (14:0) with the systematic name of n-tetradecanoic acid.
Nonanoic acid CH 3 (CH 2) 7 COOH C9:0 Capric acid: Decanoic acid CH 3 (CH 2) 8 COOH C10:0 Undecylic acid: Undecanoic acid CH 3 (CH 2) 9 COOH C11:0 Lauric acid: Dodecanoic acid CH 3 (CH 2) 10 COOH C12:0 Tridecylic acid: Tridecanoic acid CH 3 (CH 2) 11 COOH C13:0 Myristic acid: Tetradecanoic acid CH 3 (CH 2) 12 COOH C14:0 Pentadecylic acid ...
Myristyl aldehyde, also known as tetradecanal, is a reduced form of myristic acid. It is naturally produced by bioluminescent bacteria of the Vibrio genus and is one of two substrates produced and consumed by the Vibrio fischeri luciferase light emission system.
Trimyristin is a saturated fat and the triglyceride of myristic acid with the chemical formula C 45 H 86 O 6. Trimyristin is a white to yellowish-gray solid that is insoluble in water, but soluble in ethanol , acetone , benzene , chloroform , dichloromethane , ether , and TBME .
1-Tetradecanol may be prepared by the hydrogenation of myristic acid (or its esters); myristic acid itself can be found in nutmeg (from where it gains its name) but is also present in palm kernel oil and coconut oil and it is from these that the majority of 1-tetradecanol is produced. [3]
It was recently found that vitamin D 3 upregulates FACL3, which forms long-chain fatty acid synthesis through the use of myristic acid, eicosapentaenoic acid (EPA), and arachidonic acid as substrates, in expression and activity levels. [21] FACL3 contributes to vitamin D 3 growth inhibitory effect in human prostate cancer LNCaP cells. [21]