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Brenner tumours are an uncommon subtype of the surface epithelial-stromal tumour group of ovarian neoplasms. The majority are benign, but some can be malignant. [1] They are most frequently found incidentally on pelvic examination or at laparotomy. [2] Brenner tumours very rarely can occur in other locations, including the testes. [3]
Meigs syndrome may mimic other conditions, [4] since it is tumor arising from ovaries, pathology of any organs present in the abdomen may show a similar set of symptoms. . These include various gynecological disorders of the uterus such as endometrial tumor, sarcoma, leiomyoma (pseudo-Meigs syndrome); fallopian tube disorders such as hydrosalpinx, granulomatous salpingitis, fallopian tube ...
Histologically, these tumors consists of monotonous islands of granulosa cells with "coffee-bean" nuclei. That same nuclear groove appearance noted in Brenner tumour , an epithelial-stromal ovarian tumor distinguishable by nests of transitional epithelial cells (urothelial) with longitudinal nuclear grooves (coffee bean nuclei) in abundant ...
Pathology Outline, Fallopian Tubes Ogawa K, Johansson SL, Cohen SM (October 1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract" .
The tumors may be very small to very large, and may be solid or cystic. Histologically, the tumor consists of nests of the aforementioned transitional cells within surrounding tissue that resembles normal ovary. Brenner tumors may be benign or malignant, depending on whether the tumor cells invade the surrounding tissue.
For example, studies show that clear-cell tumor cells proliferate at lower rates than serous adenocarcinomas which then could aid in a lower response from clear-cell tumors to chemotherapies. [ 7 ] Given that treatment options are limited for ovarian clear-cell cancer patients, researchers are studying biomarkers or specific pathways that could ...
A fibroepithelial neoplasm (or tumor) is a biphasic tumor. They consist of epithelial tissue, and stromal or mesenchymal tissue. They may be benign or malignant. [1] Examples include: Brenner tumor of the ovary; Fibroadenoma of the breast; Phyllodes tumor of the breast; Sometimes fibroepithelial polyps (FEPs) of the vulva may be misdiagnosed as ...
Nuclear grooves (arrows indicate one of them) in papillary thyroid cancer.H&E stain. Cytopathology of papillary thyroid carcinoma, with typical features, with nuclear groove at bottom right.