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This dosage may be gradually increased to a total daily dosage of 35 mg/kg (16 mg/pound) of body weight per day or up to the development of side effects. Side effects may include increased peristalsis, diarrhea, paresthesia (tingling and numbness), and nausea. Fatal bone-marrow suppression, apparently dose related, can occur with guanidine. [7]
Guanidine exists protonated, as guanidinium, in solution at physiological pH. Guanidinium chloride (also known as guanidine hydrochloride) has chaotropic properties and is used to denature proteins. Guanidinium chloride is known to denature proteins with a linear relationship between concentration and free energy of unfolding.
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.
The general structure of a guanidine Subcategories. This category has the following 9 subcategories, out of 9 total. ... Guanidinium compounds (6 P) H ...
Guanidine nitrate; Guanidinium chloride; Guanidinium thiocyanate This page was last edited on 23 October 2021, at 14:51 (UTC). Text is available under the Creative ...
The 2025 Academy Awards were held in Los Angeles on Sunday night. Though there were many well-dressed stars, a few others missed the mark. Elle Fanning's gown was underwhelming, and Joe Locke wore ...
Acid guanidinium thiocyanate-phenol-chloroform extraction (abbreviated AGPC) is a liquid–liquid extraction technique in biochemistry and molecular biology. It is widely used for isolating RNA (as well as DNA and protein in some cases).
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