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[42] [43] [44] It has been estimated that therapeutic levels of danazol, methyltestosterone, fluoxymesterone, levonorgestrel, and norethisterone would respectively occupy or displace from testosterone 83–97%, 48–69%, 42–64%, 16–47%, and 4–39% of SHBG binding sites, while others with low affinity for SHBG such as ethinylestradiol ...
Boric acid can produce toxic effects, including death, if taken orally and/or at very high doses. [ 5 ] [ 8 ] The exact mechanism of action of boric acid as an antiseptic is unclear. [ 2 ] [ 6 ] [ 9 ] [ 10 ] Chemically , boric acid is a boron compound , or a compound containing the element boron , and is also known as trihydroxyboron .
Free Androgen Index (FAI) is a ratio used to determine abnormal androgen status in humans. The ratio is the total testosterone level divided by the sex hormone binding globulin (SHBG) level, and then multiplying by a constant, usually 100.
According to the Agency for Toxic Substances and Disease Registry, "The minimal lethal dose of ingested boron (as boric acid) was reported to be 2–3 g in infants, 5–6 g in children, and 15–20 g in adults. [...] However, a review of 784 human poisonings with boric acid (10–88 g) reported no fatalities, with 88% of cases being asymptomatic."
Vosilasarm has been assessed in clinical trials in women with breast cancer at doses ranging from 50 to 150 mg/day, with the maximum safe and tolerated dose being 100 mg/day. [ 10 ] [ 3 ] [ 2 ] The drug sold via black-market Internet suppliers and used non-medically has been reported to be taken at doses of 5 to 30 mg/day, with unknown adverse ...
"In low doses, aspirin inhibits platelets and therefore reduces blood clots." Thinning blood and therefore making clots less likely is a definite pro for those who are at higher risk of ...
With estradiol valerate, it is reported that a dose of 5 mg has a duration of 7 to 8 days, [274] 10 mg a duration of 10 to 14 days, [265] [282] 40 mg a duration of 2 to 3 weeks, and 100 mg a duration of 3 to 4 weeks. [282] High doses of estradiol valerate, such as 40 mg per week, can achieve pregnancy levels of estradiol. [283]
WASHINGTON (Reuters) -NASA affirmed on Wednesday a plan it set last year to work with Elon Musk's SpaceX in returning two astronauts from the International Space Station, saying it will do so "as ...
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