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Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects. Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be ...
Sleep can be adversely affected by benzodiazepine dependence. Possible adverse effects on sleep include induction or worsening of sleep disordered breathing. Like alcohol, benzodiazepines are commonly used to treat insomnia in the short term (both prescribed and self-medicated), but worsen sleep in the long term.
Evidence from reviews of benzodiazepine tolerance mechanisms [42] and clonazepam use in psychiatric disorders [43] is strongly discordant with the claim that benzodiazepines lose anxiolytic efficacy over a period of weeks, as these reviews present RCT evidence of continued anxiolytic efficacy at up to 22 weeks [44] and observational (open-label ...
Clonazepam, also known by its brand name Klonopin, is a drug used to anxiety, seizures and panic disorder.
In photos provided by Pennsylvania-based company it shows the potential mislabeling of a package of the Clonazepam tablets, USP 2 mg lot 550176501 with a carton description and NDC code of ...
Before starting a treatment with clonazepam, a screening for obstructive sleep apnea should performed. [22] However, clonazepam needs to be manipulated carefully because of its significant side effects, i.e., morning confusion or memory impairment, [22] mainly in patients with neurodegenerative disorders such as dementia. [26]
Melatonin and clonazepam are the most frequently used, [2] and are comparably effective, [24] but melatonin offers a safer alternative, because clonazepam can produce undesirable side effects. [17] Medications that may worsen RBD and should be stopped if possible are tramadol, mirtazapine, antidepressants, and beta blockers. [2]
A review of clonazepam use in psychiatric disorders reported longitudinal evidence of continued anxiolytic efficacy for up to 3 years [19], and a meta-analysis of long-term benzodiazepine use found no difference in outcome between benzodiazepines and antidepressants after 8 weeks. [20]
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