enow.com Web Search

Search results

  1. Results from the WOW.Com Content Network
  2. BRAF inhibitor - Wikipedia

    en.wikipedia.org/?title=BRAF_inhibitor&redirect=no

    Download as PDF; Printable version; ... Redirect page. Redirect to: BRAF (gene)#BRAF inhibitors in the clinic ... Text is available under the Creative Commons ...

  3. BRAF (gene) - Wikipedia

    en.wikipedia.org/wiki/BRAF_(gene)

    BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf. [5] [6] The B-Raf protein is involved in sending signals inside cells which are involved in directing ...

  4. MAPK/ERK pathway - Wikipedia

    en.wikipedia.org/wiki/MAPK/ERK_pathway

    Furthermore, the pathway has been shown to encode the strength of signaling inputs though frequency modulated pulses of its activity. Using live cell FRET biosensors, cells induced with different concentrations of EGF illicit activity bursts of different frequency, where higher levels of EGF resulted in more frequent bursts of ERK activity.

  5. Encorafenib - Wikipedia

    en.wikipedia.org/wiki/Encorafenib

    Encorafenib, sold under the brand name Braftovi, is an anti-cancer medication used for the treatment of certain melanoma cancers. It is a small molecule BRAF inhibitor [4] that targets key enzymes in the MAPK signaling pathway.

  6. CRISPR activation - Wikipedia

    en.wikipedia.org/wiki/CRISPR_activation

    In another dCas-SAM system experiment, Konermann et al. (2015) found genes in melanoma cells that give resistance to a BRAF inhibitor through activating candidate genes via dCas system. [7] Thus, the dCas9-SAM system can further be employed to activate latent genes, develop gene therapies, and discover new genes.

  7. Mitogen-activated protein kinase - Wikipedia

    en.wikipedia.org/wiki/Mitogen-activated_protein...

    They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis. [1] MAP kinases are found in eukaryotes only, but they are fairly diverse and encountered in all animals, fungi and plants, and even in an array of unicellular eukaryotes. [citation needed]

  8. Category:B-Raf inhibitors - Wikipedia

    en.wikipedia.org/wiki/Category:B-Raf_inhibitors

    A B-Raf inhibitor is an anticancer drug that inhibits the normal or mutated B-raf gene. Pages in category "B-Raf inhibitors" The following 3 pages are in this category, out of 3 total.

  9. Systemic acquired resistance - Wikipedia

    en.wikipedia.org/wiki/Systemic_acquired_resistance

    Systemic acquired resistance (SAR) is a "whole-plant" resistance response that occurs following an earlier localized exposure to a pathogen.SAR is analogous to the innate immune system found in animals, and although there are many shared aspects between the two systems, it is thought to be a result of convergent evolution. [1]