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An insulin analog (also called an insulin analogue) is any of several types of medical insulin that are altered forms of the hormone insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of controlling blood glucose levels in diabetes.
Insulin is regulated as a biologic rather than as a drug. [103] The changed status gives the FDA more flexibility for approval and labeling. [104] In July 2021, the FDA approved insulin glargine-yfgn (Semglee), a biosimilar product that contains the long acting analog insulin glargine. [105]
It works the same as human insulin by increasing the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver. [5] Insulin lispro was first approved for use in the United States in 1996. [5] [8] [9] It is a manufactured analogue of human insulin where two amino acids have swapped positions. [10]
Insulin glargine sold under the brand name Lantus among others is a long-acting modified form of medical ... a long-acting insulin analog. [12] Mixing with other insulins
Insulin degludec (INN/USAN) is an ultralong-acting basal insulin analogue that was developed by Novo Nordisk under the brand name Tresiba. [7] It is administered via subcutaneous injection to help control the blood sugar level of those with diabetes .
Likewise, another protracted insulin analogue is based on a fatty acid acylation approach. A myristic acid molecule is attached to this analogue, which associates the insulin molecule to the abundant serum albumin, which in turn extends the effect and reduces the risk of hypoglycemia. Both protracted analogues need to be taken only once daily ...
Insulin icodec, sold under the brand name Awiqli, is a medication used for the treatment of diabetes to improve glycemic control. [3] It is an ultralong-acting basal insulin analogue that is developed by Novo Nordisk .
The insulin aspart protamine portion is a crystalline form of insulin aspart, which delays the action of the insulin, giving it a prolonged absorption profile after injection. [14] The combination of the fast-acting form and the long-acting form allows the patient to receive fewer injections over the course of the day.