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Facioscapulohumeral muscular dystrophy (FSHD) is a type of muscular dystrophy, a group of heritable diseases that cause degeneration of muscle and progressive weakness. Per the name, FSHD tends to sequentially weaken the muscles of the face, those that position the scapula, and those overlying the humerus bone of the upper arm.
The causes listed are relatively immediate medical causes, but the ultimate cause of death might be described differently. For example, tobacco smoking often causes lung disease or cancer, and alcohol use disorder can cause liver failure or a motor vehicle accident.
The exact pathophysiology of Monckeberg's arteriosclerosis remains uncertain. However, it is thought that the condition arises from the fatty degeneration of smooth muscle cells within the arterial media, leading to the formation of a mass that undergoes hyaline degeneration and eventually calcification.
Trauma is a leading cause of morbidity and mortality across all age groups, however, geriatric populations are unique compared to younger counterparts in the amount of existing health issues and inherent risk of disability and death. [4] As a whole, older populations are more vulnerable to trauma from minor mechanisms of injury and less able to ...
Frail elderly people are at significant risk of post-surgical complications and the need for extended care. Frailty more than doubles the risk of morbidity and mortality from surgery and cardiovascular conditions. [59] Assessment of older patients before elective surgeries can accurately predict the patients' recovery trajectories. [60]
Losmapimod (GW856553X) is an investigational drug that reached stage III clinical trials for multiple medical conditions, but did not prove efficacy. It was most recently in development by Fulcrum Therapeutics for the treatment of facioscapulohumeral muscular dystrophy (FSHD).
Cause of death Number Percent of total Notes Adverse events in hospitals in low- and middle-income countries: 2.6 million deaths [13] "one of the 10 leading causes of death and disability in the world" Smoking tobacco: 435,000 [11] 18.1%: Obesity: 111,900 [14] 4.6%: There was considerable debate about the differences in the numbers of obesity ...
In patients with sepsis, septic shock, or multiple organ dysfunction syndrome that is due to major trauma, the rs1800625 polymorphism is a functional single nucleotide polymorphism, a part of the receptor for advanced glycation end products (RAGE) transmembrane receptor gene (of the immunoglobulin superfamily) and confers host susceptibility to ...