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Auto-brewery syndrome (ABS) (also known as gut fermentation syndrome, endogenous ethanol fermentation or drunkenness disease) is a condition characterized by the fermentation of ingested carbohydrates in the gastrointestinal tract of the body caused by bacteria or fungi. [1]
These adverse effects are believed to be due to the neurotoxic effects of repeated withdrawal from alcohol on aberrant neuronal plasticity and cortical damage. Repeated periods of acute intoxication followed by acute detoxification has profound effects on the brain and is associated with an increased risk of seizures as well as cognitive deficits.
An abnormal liver will take longer but still succeeds, provided the alcohol does not cause liver failure. [34] People having drunk heavily for several days or weeks may have withdrawal symptoms after the acute intoxication has subsided. [35]
In mid-2017, it was reported that one company in the UK allows sick days when hung over. [ 66 ] As of 2019, South Korea's 'hangover-cure product' market, which comes in various formulations such as beverages, pills, and jelly, is a 250 billion won (US$213 million) industry.
The different isoforms of ADH showed protection against alcoholic disorders in Han Chinese and Japanese (due to presence of ADH1B*2 ) and in African (due to presence of ADH1B*3). [25] On the other hand, presence of ALDH2*2 in East Asians (a variant of the ALDH gene), can cause blood acetaldehyde levels of 30 to 75 μM or higher, which is more ...
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Sobriety is the condition of not having any effects from alcohol and other drugs. [1] Sobriety is also considered to be the natural state of a human being at birth. A person in a state of sobriety is considered sober. Organizations of the temperance movement have encouraged sobriety as being normative in society. [2]