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Excessive QT prolongation can trigger tachycardias such as torsades de pointes (TdP). QT prolongation is an established side effect of antiarrhythmics, but can also be caused by a wide range of non-cardiac medicines, including antibiotics, antidepressants, antihistamines, opioids, and complementary medicines.
AZCERT developed the Adverse Drug Event Causality Analysis (ADECA) to evaluate drugs for their risk of causing QT prolongation and TdP. [11] As part of its ADECA reviews, AZCERT includes drugs marketed outside the United States, especially in Europe, Japan, and Canada. In addition to their use to inform healthcare decision-making, CredibleMeds ...
Although topiramate does inhibit high-voltage-activated calcium channels, its relevance to clinical activity is uncertain. Effects on specific GABA-A receptor isoforms could also contribute to the antiseizure activity of the drug. Topiramate selectively inhibits cytosolic (type II) and membrane-associated (type IV) forms of carbonic anhydrase.
Topiramate side effects exist. And they go beyond weight loss. Look out for fatigue, dizziness and mood changes, and contact a healthcare professional if you notice anything off.
There’re at least 10 specific gene mutations that are known to be linked to Long QT syndrome, which are referred to as, for example, LQT1, LQT2, and so on, all of which have some effect on one or more ion channels. Aside from congenital causes though, sometimes the QT interval can be prolonged by certain medications which affect ion channels.
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
Bedroom side effects. Anorgasmia (difficulty experiencing climax) is a noted side effect of Lexapro. ... If you have a history of heart problems — such as QT prolongation and heart rhythm ...
Can prolong the QT interval, some in vivo evidence [36] suggests it may have anti-diabetogenic effects and hence may improve metabolic parameters in patients on clozapine. Aripiprazole: Global, esp. negative: Akathisia: 1 DB-RPCT: 61: Can also improve metabolic side effects of clozapine (including body weight). Six studies so far; only one ...
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