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Fluid attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) is a radiographic marker seen on brain imaging in acute ischaemic stroke. FVH can be used as a proxy for slow leptomeningeal collateral blood flow, and may help reveal which areas of brain tissue are potentially salvageable. [12]
In brain tissue, a biochemical cascade known as the ischemic cascade is triggered when the tissue becomes ischemic, potentially resulting in damage to and the death of brain cells. Medical professionals must take steps to maintain proper CBF in patients who have conditions like shock, stroke, cerebral edema, and traumatic brain injury.
Information about the structure and function of the human brain comes from a variety of experimental methods, including animals and humans. Information about brain trauma and stroke has provided information about the function of parts of the brain and the effects of brain damage. Neuroimaging is used to visualise the brain and record brain ...
A network of blood vessels travels to the brain and spinal cord by interlacing through the pia membrane. These capillaries are responsible for nourishing the brain. [8] This vascular membrane is held together by areolar tissue covered by mesothelial cells from the delicate strands of connective tissue called the arachnoid trabeculae.
The arachnoid mater makes arachnoid villi, small protrusions through the dura mater into the venous sinuses of the brain, which allow CSF to exit the subarachnoid space and enter the blood stream. Unlike the dura mater, which receives a rich vascular supply from numerous arteries, the arachnoid mater is avascular (lacking blood vessels).
The cells of the neurovascular unit also make up the blood–brain barrier (BBB), which plays an important role in maintaining the microenvironment of the brain. [11] In addition to regulating the exit and entrance of blood, the blood–brain barrier also filters toxins that may cause inflammation, injury, and disease. [12]
These sinuses play a crucial role in cerebral venous drainage. A dural venous sinus, in human anatomy, is any of the channels of a branching complex sinus network that lies between layers of the dura mater, the outermost covering of the brain, and functions to collect oxygen-depleted blood. Unlike veins, these sinuses possess no muscular coat.
However, considering that the circle of Willis is present in many non-human species (reptiles, birds and mammals), and that arterial narrowing is mostly associated with old age and the human lifestyle, more generally applicable explanations of its functions have been suggested, such as dampening of pulse pressure waves within the brain [7] and ...