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Ephedrine works by inducing the release of norepinephrine and hence indirectly activating the α-and β-adrenergic receptors. [11] Chemically, ephedrine is a substituted amphetamine and is the (1R,2S)-enantiomer of β-hydroxy-N-methylamphetamine. [14] Ephedrine was first isolated in 1885 and came into commercial use in 1926.
Chelate complex of the Chen-Kao reaction starting from (1S,2S)-pseudoephedrine. The Chen-Kao reaction (named after Ko Kuei Chen and Chung-Hsi Kao, Madison, Wisconsin 1926) [1] [2] is a chemical method for determining the presence of pseudoephedrine, ephedrine, and similar phenylalkylamines. [3]
Amphetamine was first synthesized in 1887 in Germany by Romanian chemist, Lazăr Edeleanu, who named the drug phenylisopropylamine. [4] [3] [18] [2] This concoction was one of a series of compounds related to the plant derivative ephedrine, which had been isolated from the Chinese ephedra plant that same year by Nagai Nagayoshi. [6]
Ephedrine is the N-methyl analogue of phenylpropanolamine. Exogenous compounds in this family are degraded too rapidly by monoamine oxidase to be active at all but the highest doses. [51] However, the addition of the α-methyl group allows the compound to avoid metabolism and confer an effect. [51]
Bottle of ephedrine, an alkaloid found in ephedra. Ephedra is a medicinal preparation from the plant Ephedra sinica. [1] Several additional species belonging to the genus Ephedra have traditionally been used for a variety of medicinal purposes, and are a possible candidate for the soma plant of Indo-Iranian religion. [2]
A combination of theophylline, ephedrine, and hydroxyzine has been marketed under the brand name Marax among others as well. [16] [17] [18] Combinations of theophylline, ephedrine, and a barbiturate were later phased out in favor of combinations of theophylline and ephedrine alone (e.g., brand name Franol).
Additionally, Ephedrine acts as an anorectic, or appetite-suppressing drug. However, the anorectic effect becomes less pronounced over time, as the body becomes tolerant of ephedrine to some degree. An estimated 75% of the efficacy of the ECA stack can be attributed to decreased appetite, while the remaining 25% is due to the thermogenic ...
Ephedrine's alpha-adrenergic stimulation causes contraction of the smooth muscle at the base of the bladder, resulting in resistance to urine output. It is, therefore, the use of Tedral in patients with urinary retention and prostatic hyperplasia has to be cautious.