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Diabetic retinopathy (also known as diabetic eye disease) is a medical condition in which damage occurs to the retina due to diabetes.It is a leading cause of blindness in developed countries and one of the lead causes of sight loss in the world, even though there are many new therapies and improved treatments for helping people live with diabetes.
GLP-1 plays a key role in stimulating insulin production and regulating blood sugar levels (glucose). ... Diabetic retinopathy is a serious eye condition that can affect folks with diabetes ...
Aldose reductase activity increases as the glucose concentration rises in diabetes in those tissues that are not insulin sensitive, which include the lenses, peripheral nerves, and glomerulus. Sorbitol does not diffuse through cell membranes easily and therefore accumulates, causing osmotic damage which leads to retinopathy and neuropathy.
Diabetic retinopathy complications (an eye disease) Hypoglycemia (low blood sugar) if you take an insulin secretagogue or insulin. ... Naltrexone is commonly used to treat alcohol and drug ...
In patients with diabetes, this may be caused by several factors, such as too much or incorrectly timed insulin, too much or incorrectly timed exercise (exercise decreases insulin requirements) or not enough food (specifically glucose containing carbohydrates). The variety of interactions makes cause identification difficult in many instances.
Treatment is based on the cause of the retinopathy and may include laser therapy to the retina. Laser photocoagulation therapy has been the standard treatment for many types of retinopathy. Evidence shows that laser therapy is generally safe and improves visual symptoms in sickle cell and diabetic retinopathy.
Intraretinal microvascular abnormalities (IRMA) are abnormalities of the blood vessels that supply the retina of the eye, a sign of diabetic retinopathy. [1] IRMA can be difficult to distinguish from and is likely a precursor to retinal neovascularization. One way to distinguish IRMA from retinal neovascularization is to perform fluorescein ...
The pathway is implicated in diabetic complications, especially in microvascular damage to the retina, [2] kidney, [3] and nerves. [ 4 ] Sorbitol cannot cross cell membranes , and, when it accumulates, it produces osmotic stresses on cells by drawing water into the insulin-independent tissues.
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