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A vitamin B12 level of less than 200 pg/mL is considered deficient. Treatment First, have your health care provider run blood tests to see if you truly have a B12 deficiency.
Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says.
A diagnosis of vitamin B 12 deficiency is determined by blood levels lower than 200 or 250 picograms per ml (148 or 185 picomoles per liter). Measurement of blood methylmalonic acid (MMA), a vitamin B 12-associated metabolite, is a commonly used biomarker. [2] Deficiency is often suspected first, as diagnosis usually requires several tests.
How vitamin B12 deficiency is detected If a doctor suspects a vitamin B12 deficiency, they will usually order blood work to check a patient’s levels, Kaiser says.
Reduced serum levels of vitamin B 12 occur in up to 30% of people taking long-term anti-diabetic metformin. [105] [106] Deficiency does not develop if dietary intake of vitamin B 12 is adequate or prophylactic B 12 supplementation is given. If the deficiency is detected, metformin can be continued while the deficiency is corrected with B 12 ...
Serum vitamin B 12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
Here’s what we know about low vitamin B12 levels and thinning hair. Metformin and Vitamin B12 Vitamin B12 deficiency is associated with a number of problems, including weakness, weight loss ...
[56] [57] Low levels of serum vitamin B 12 may be caused by other factors than B 12 deficiency, such as folate deficiency, pregnancy, oral contraceptive use, haptocorrin deficiency, and myeloma. [57] High serum levels may caused by supplementing with vitamin B 12, present of antibodies to intrinsic factor, or due to underlying condition. [56]
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