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The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
The free radical theory proposes that ageing is the cumulative result of oxidative damage to the cells and tissues of the body that arises primarily as a result of aerobic metabolism.
The free-radical theory of aging was formally proposed by Denham Harman in 1956 and postulates that the inborn process of aging is caused by cumulative oxidative damage to cells by free radicals produced during aerobic respiration. Free radicals are atoms or molecules with single unpaired electrons.
Miquel's contribution to the free radical theory of aging was important in pointing out mitochondria as sources of free radicals and mitochondrial deoxyribonucleic acid (DNA) as a critical target to explain the age-associated damage in cells.
According to this theory, rampant oxidation mangles more and more lipids, proteins, snippets of DNA and other key components of cells over time, eventually compromising tissues and organs and...
The free radical theory of the aging process is based on the hypothesis that with increasing age, mutations of the mitochondrial DNA will accumulate and will at least lead to a loss of function with subsequent acceleration of cell death.
According to the free radical theory of aging, first outlined in 1956, free radicals break cells down over time. As the body ages, it loses its ability to fight the effects of free radicals.
The free radical theory of aging, one of the nine suggested hallmarks of aging (López-Otín et al., 2016), implicates the gradual accumulation of oxidative cellular damage as a fundamental driver of cellular aging (Harman, 1956; Miquel et al., 1980).
The free radical theory of aging, one of the nine suggested hallmarks of aging (López-Otín et al., 2016), implicates the gradual accumulation of oxidative cellular damage as a fundamental driver of cellular aging (Harman, 1956; Miquel et al., 1980).
Harman’s Free Radical Theory of Aging has been considered as a major theory of aging for more than 50 years. In 1956 Dr. Harman proposed that the accumulation of free radicals with the age causes the damage of biomolecules by these reactive species and the development of pathological disorders resulting in cell senescence and organismal aging.