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A 3D cell culture is an artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. Unlike 2D environments (e.g. a Petri dish), a 3D cell culture allows cells in vitro to grow in all directions, similar to how they would in vivo. [1]
Cell-based models are mathematical models that represent biological cells as discrete entities. Within the field of computational biology they are often simply called agent-based models [1] of which they are a specific application and they are used for simulating the biomechanics of multicellular structures such as tissues. to study the influence of these behaviors on how tissues are organised ...
Different cell lines and cell types have been cultured in NFC, including e.g. differentiation of human hepatic cells to functional organotypic cultures, [8] and proliferation of human pluripotent stem cells. [4] Organotypic liver cell cultures can be used in drug discovery for testing liver toxicity and metabolism of the novel drug candidates.
3D cell-culture models exceed 2D culture systems by promoting higher levels of cell differentiation and tissue organization. 3D culture systems are more successful because the flexibility of the ECM gels accommodates shape changes and cell-cell connections – formerly prohibited by rigid 2D culture substrates.
Different models of 3D printing tissue and organs. Three dimensional (3D) bioprinting is the use of 3D printing–like techniques to combine cells, growth factors, bio-inks, and biomaterials to fabricate functional structures that were traditionally used for tissue engineering applications but in recent times have seen increased interest in other applications such as biosensing, and ...
Originally the L-systems were devised to provide a formal description of the development of such simple multicellular organisms, and to illustrate the neighbourhood relationships between plant cells. Later on, this system was extended to describe higher plants and complex branching structures.
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Design can be database-driven and based on existing parts lists. P&ID diagrams can be used to form the basis of 2D layouts and 3D designs, with the ability to cross-check P&IDs and automatically load P&ID components not yet included in a 3D plant design in the appropriate position. MPDS4 Factory Layout offers a hybrid 2D/3D design environment
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