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  2. Confocal microscopy - Wikipedia

    en.wikipedia.org/wiki/Confocal_microscopy

    Fluorescence and confocal microscopes operating principle. Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser scanning confocal microscopy (LSCM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. [1]

  3. Optical transfer function - Wikipedia

    en.wikipedia.org/wiki/Optical_transfer_function

    In both cases the numerical aperture of the objective is 1.49 and the refractive index of the medium 1.52. The wavelength of the emitted light is assumed to be 600 nm and, in case of the confocal microscope, that of the excitation light 500 nm with circular polarization. A section is cut to visualize the internal intensity distribution.

  4. Optical instrument - Wikipedia

    en.wikipedia.org/wiki/Optical_instrument

    An optical instrument is a device that processes light waves (or photons), either to enhance an image for viewing or to analyze and determine their characteristic properties. Common examples include periscopes, microscopes, telescopes, and cameras. [1] [2]

  5. Optical spectrometer - Wikipedia

    en.wikipedia.org/wiki/Optical_spectrometer

    A spectrograph typically has a multi-channel detector system or camera that detects and records the spectrum of light. [ 11 ] [ 12 ] The term was first used in 1876 by Dr. Henry Draper when he invented the earliest version of this device, and which he used to take several photographs of the spectrum of Vega .

  6. Microscopy - Wikipedia

    en.wikipedia.org/wiki/Microscopy

    Antonie van Leeuwenhoek (1632–1723). The field of microscopy (optical microscopy) dates back to at least the 17th-century.Earlier microscopes, single lens magnifying glasses with limited magnification, date at least as far back as the wide spread use of lenses in eyeglasses in the 13th century [2] but more advanced compound microscopes first appeared in Europe around 1620 [3] [4] The ...

  7. Objective (optics) - Wikipedia

    en.wikipedia.org/wiki/Objective_(optics)

    Several objective lenses on a microscope. Objective lenses of binoculars. In optical engineering, an objective is an optical element that gathers light from an object being observed and focuses the light rays from it to produce a real image of the object. Objectives can be a single lens or mirror, or combinations of several optical elements.

  8. Photographic lens design - Wikipedia

    en.wikipedia.org/wiki/Photographic_lens_design

    The design of the lens is required to work effectively with light passing from near focus to far focus - exactly the reverse of a camera lens. This demands that internal light baffling within the lens is designed differently and that the individual lens elements are designed to maximize performance for this change of direction of incident light.

  9. Super-resolution microscopy - Wikipedia

    en.wikipedia.org/wiki/Super-resolution_microscopy

    By 1978, the first theoretical ideas had been developed to break the Abbe limit, which called for using a 4Pi microscope as a confocal laser-scanning fluorescence microscope where the light is focused from all sides to a common focus that is used to scan the object by 'point-by-point' excitation combined with 'point-by-point' detection. [14]

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