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  2. P3 peptide - Wikipedia

    en.wikipedia.org/wiki/P3_peptide

    p3 peptide also known as amyloid β- peptide (Aβ) 17–40/42 is the peptide resulting from the α-and γ-secretase cleavage from the amyloid precursor protein ().It is known to be the major constituent of diffuse plaques observed in Alzheimer's disease (AD) brains and pre-amyloid plaques in people affected by Down syndrome.

  3. Amyloid - Wikipedia

    en.wikipedia.org/wiki/Amyloid

    Amyloid is formed through the polymerization of hundreds to thousands of monomeric peptides or proteins into long fibers. Amyloid formation involves a lag phase (also called nucleation phase), an exponential phase (also called growth phase) and a plateau phase (also called saturation phase), as shown in the figure.

  4. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...

  5. Amyloidosis - Wikipedia

    en.wikipedia.org/wiki/Amyloidosis

    As a result, amyloid deposits into the body's extracellular space. [5] The process of forming amyloid fibrils is thought to have intermediate oligomeric forms. Both the oligomers and amyloid fibrils can be toxic to cells and can interfere with proper organ function. [21]

  6. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). [24] APP is produced by many types of cell in the body, but it is especially abundant in neurons. It is a single-pass transmembrane protein, passing once through cellular membranes.

  7. Amyloid-beta precursor protein - Wikipedia

    en.wikipedia.org/wiki/Amyloid-beta_precursor_protein

    The amyloid-β precursor protein (AβPP), and all associated secretases, are expressed early in development and play a key role in the endocrinology of reproduction – with the differential processing of AβPP by secretases regulating human embryonic stem cell (hESC) proliferation as well as their differentiation into neural precursor cells (NPC).

  8. Serum amyloid A1 - Wikipedia

    en.wikipedia.org/wiki/Serum_amyloid_A1

    Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. [ 5 ] [ 6 ] [ 7 ] SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. [ 8 ]

  9. Serum amyloid P component - Wikipedia

    en.wikipedia.org/wiki/Serum_amyloid_P_component

    20219 Ensembl ENSG00000132703 ENSMUSG00000026542 UniProt P02743 P12246 RefSeq (mRNA) NM_001639 NM_011318 RefSeq (protein) NP_001630 NP_035448 Location (UCSC) Chr 1: 159.59 – 159.59 Mb Chr 1: 172.72 – 172.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serum amyloid P component (SAP) is the identical serum form of the amyloid P component (AP), a 25 kDa pentameric protein ...