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Equine estrogens, or horse estrogens, are estrogens found in horses. [1] [2] [3] They include the following: [1] [2] [3] Estradiol; Estrone; Equilin (Δ 7-estrone) Equilenin (Δ 6,8-estrone) 17α-Dihydroequilin (Δ 7-17α-estradiol) 17β-Dihydroequilin (Δ 7-17β-estradiol) 17α-Dihydroequilenin (Δ 6,8-17α-estradiol) 17β-Dihydroequilenin (Δ ...
Some lesser known uses are as a means of high-dose estrogen therapy in the treatment of breast cancer in both women and men and in the treatment of prostate cancer in men. [ 27 ] [ 28 ] It has been used at a dosage of 2.5 mg three times per day (7.5 mg/day total) for prostate cancer.
8,9-Dehydroestradiol, or Δ 8-17β-estradiol, also known as estra-1,3,5(10),8-tetraen-17β-ol-3-one, is a naturally occurring steroidal estrogen found in horses which is closely related to equilin, equilenin, and estradiol, and, as the 3-sulfate ester sodium salt, is a minor constituent of conjugated estrogens (Premarin). [1]
This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead. Estradiol derivatives
Conjugated estrogens/medroxyprogesterone acetate (CEs/MPA), sold under the brand names Prempro and Premphase, is a combination product of conjugated equine estrogens (Premarin), an estrogen collected from horse urine, and medroxyprogesterone acetate (Provera), a progestogen, which is used in menopausal hormone therapy for the treatment of menopausal symptoms.
The hormone estriol, produced during pregnancy, is frequently compounded into bioidentical preparations in the United States. While some think it to be a weaker estrogen, with a more limited period of effectiveness than estradiol, it has been demonstrated to be a stronger estrogen in certain ways. [22]
Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).
Estradiol valerate was first described in 1940 and was introduced for medical use in 1954. [19] [20] [21] Along with estradiol cypionate, it is one of the most widely used esters of estradiol. [22] Estradiol valerate is used in the United States, Canada, Europe, and throughout much of the rest of the world. [23] [24] It is available as a ...