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The latter is far from optimal, but the former, which changes only one variable at a time, is worse. See also the factorial experimental design methods pioneered by Sir Ronald A. Fisher. Reasons for disfavoring OFAT include: OFAT requires more runs for the same precision in effect estimation; OFAT cannot estimate interactions
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The use of a sequence of experiments, where the design of each may depend on the results of previous experiments, including the possible decision to stop experimenting, is within the scope of sequential analysis, a field that was pioneered [13] by Abraham Wald in the context of sequential tests of statistical hypotheses. [14]
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In statistics, Box–Behnken designs are experimental designs for response surface methodology, devised by George E. P. Box and Donald Behnken in 1960, to achieve the following goals: Each factor, or independent variable, is placed at one of three equally spaced values, usually coded as −1, 0, +1.
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