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Dulaglutide, sold under the brand name Trulicity among others, [8] is a medication used for the treatment of type 2 diabetes in combination with diet and exercise. [9] [10] It is also approved in the United States for the reduction of major adverse cardiovascular events in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors.
As a result, different GLP-1 agonist drugs are modified in various ways to extend the half-life, resulting in drugs that can be dosed multiple times per day, daily, weekly, or less often. [29] Most synthetic GLP-1 agonists are delivered via subcutaneous injection , which is a barrier to their use and reason for discontinuation. [ 37 ]
A combined result of 5 RCTs enlisting a total of 279 patients aged 65 or older (mean baseline HbA1c of 8%) receiving 5 mg/d of saxagliptin was shown to reduce HbA1c by 0.73%. [45] A combined result of 5 RCTs enlisting a total of 238 patients aged 65 or older (mean baseline HbA1c of 8.6%) receiving 100 mg/d of vildagliptin was shown to reduce ...
The discount rate is commonly used for U.S. Treasury bills and similar financial instruments. For example, consider a government bond that sells for $95 ('balance' in the bond at the start of period) and pays $100 ('balance' in the bond at the end of period) in a year's time. The discount rate is
Using a fixed combination of an ACE inhibitor and a chlorosulfamoyl diuretic leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately, in addition to those due to the additive synergistic action of the two constituents, when combined, on vascular endothelium ...
The BBC also receives some funding from the Scottish Government via MG Alba to finance the BBC Alba Gaelic-language television service in Scotland. The BBC used to receive a direct government grant from the Foreign and Commonwealth Office to fund television and radio services broadcast to other countries, such as the BBC World Service radio and ...
[1] [5] There are both external condoms, also called male condoms, and internal (female) condoms. [ 6 ] [ 7 ] The external condom is rolled onto an erect penis before intercourse and works by forming a physical barrier which limits skin-to-skin contact, exposure to fluids , and blocks semen from entering the body of a sexual partner.
It is strongly dose-dependent: for the immediate release preparation, the seizure incidence is 0.4% at the dose 300–450 mg per day; the incidence climbs almost ten-fold for the higher than recommended dose of 600 mg. [10] [11] For comparison, the incidence of unprovoked seizure in the general population is 0.07–0.09%, and the risk of ...