Search results
Results from the WOW.Com Content Network
The drugs they studied included cocaine and a few others that have some similarities to cocaine in how they affect the brain. They trained the monkeys to give themselves these drugs through injections and observed their behavior. They wanted to see if the drugs had similar effects on the monkeys.
JHW-007 is a cocaine analogue and a high affinity atypical dopamine reuptake inhibitor that is being researched for the treatment of cocaine addiction.JHW-007 has been found to blunt the psychostimulant effects of cocaine and reduce self-administration in rodents. [1]
Hence, it should be borne in mind that these neurotransmitters are unlikely to be involved in the addiction forming properties of cocaine and related stimulants. Nevertheless, they are still behaviorally active and will contribute to the effects that such drugs elicit in their users.
Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...
Levodopa can cross the blood–brain barrier and increases dopamine levels in the substantia nigra, thus alleviating the symptoms of Parkinson's disease. The drawback of levodopa treatment is that it treats the symptoms of Parkinson's (low dopamine levels), rather than the cause (the death of dopaminergic neurons in the substantia nigra).
Prior to that year, most cases of death by cocaine intoxication [37] during the cocaine epidemic that happened in a sudden manner. This involved the exposure to highly toxic amounts of the drug due to the bursting of cocaine packets being carried within the body by "body stuffers". [ 38 ]
San Diego sector Border Patrol agents announced the seizure of more than 80 pounds of cocaine in Temecula. The drugs were stashed inside an SUV's false dashboard, authorities said.
The effects of KOR agonism on dopamine systems are well documented, and recent work also implicates the mitogen-activated protein kinase cascade and pCREB in KOR-dependent behaviors. [ 40 ] [ 81 ] While the predominant drugs of abuse examined have been cocaine (44%), ethanol (35%), and opioids (24%). [ 82 ]