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Pagetoid is a term used in dermatology to refer to "upward spreading" of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below.
ThinPrep pap smear with group of normal cervical cells on left and HPV-infected cells showing features typical of koilocytes: enlarged (x2 or x3) nuclei and hyperchromasia. A koilocyte is a squamous epithelial cell that has undergone a number of structural changes, which occur as a result of infection of the cell by human papillomavirus (HPV). [1]
Touton giant cells are also referred to as xanthelasmatic cells due to the fact they are found in lesions associated with xanthomas which are skin growths with yellow, lipid filled deposits. Touton giant cells are often frequently observed in granulomatous inflammation, which is a type of inflammation caused by the clustering of immune cells ...
In dermatopathology, the Tzanck test, also Tzanck smear, is scraping of an ulcer base to look for Tzanck cells. It is sometimes also called the chickenpox skin test and the herpes skin test. It is a simple, low-cost, and rapid office based test. [1] Tzanck cells (acantholytic cells) are found in: Herpes simplex [2] Varicella and herpes zoster
Download as PDF; Printable version; In other projects ... Atypical lichen myxedematosus is a skin condition caused by fibroblasts producing abnormally large amounts ...
Atypical fibroxanthoma (AFX) of the skin is a low-grade malignancy related to malignant fibrous histiocytoma, which it resembles histologically. [ 2 ] : 613 Atypical fibroxanthoma manifests as a hard, pink or red papule or nodule that grows over the course of several months and may bleed or ulcerate .
Large melanocytic cells with nest formation along the dermo-epidermal junction. Invasion of the upper epidermis in a pagetoid fashion (discohesive single cell growth). The pattern of rete ridges is often effaced. Invasion of the dermis by atypical, pleomorphic melanocytes; Absence of the 'maturation' typical of naevus cells; Mitoses
The CDKN2A gene is located on chromosome 9p21.3. Two main transcripts, isoforms '1' and '4', each contain three exons and span 7288 and 26740 bp, respectively. They encode proteins of 156 and 173 amino acids; isoform '1' encodes p16(INK4a), while isoform '4' encodes p14(ARF), a protein that is structurally unrelated to p16(INK4) but acts in cell cycle G1 control by stabilizing the tumor ...