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Pagetoid is a term used in dermatology to refer to "upward spreading" of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below.
Mycosis fungoides is caused by abnormal white blood cells (T-lymphocytes). These abnormal cells have a preference for localizing and proliferating uncontrolled in the outer layer of the skin . The abnormal cells may later involve other organs such as the lymph nodes. It is hypothesized that the genetic mutations in these cancer cells lead to ...
Download as PDF; Printable version; ... Dermatology: Atypical lichen myxedematosus is a skin condition caused by fibroblasts producing abnormally large amounts of ...
Atypical fibroxanthoma (AFX) of the skin is a low-grade malignancy related to malignant fibrous histiocytoma, which it resembles histologically. [ 2 ] : 613 Atypical fibroxanthoma manifests as a hard, pink or red papule or nodule that grows over the course of several months and may bleed or ulcerate .
Lutzner cells are found in skin tissue, more specifically, the epidermis and dermis layers. An accumulation of Lutzner cells in the layers of the skin can cause cutaneous T-cell lymphoma. Cutaneous cell lymphoma is the second most common form of non-Hodgkin's lymphoma. [11] Two forms of cutaneous T-cell lymphoma associated with abnormal T ...
Because of abnormal peripheral blood profile, response to inflammatory skin conditions with patients with myelomonocytic leukemia can have appearance of atypical cells at sites of inflammation, confusing the Mohs surgeon. [6]: 446 Perineural spread, and benign changes simulating perineural spread. Tumor spreading along a nerve can be difficult ...
In dermatopathology, the Tzanck test, also Tzanck smear, is scraping of an ulcer base to look for Tzanck cells. It is sometimes also called the chickenpox skin test and the herpes skin test. It is a simple, low-cost, and rapid office based test. [1] Tzanck cells (acantholytic cells) are found in: Herpes simplex [2] Varicella and herpes zoster
Sézary cell: pleomorphic abnormal T cell with the characteristic cerebriform nuclei (Peripheral blood - MGG stain) Sézary disease and mycosis fungoides are cutaneous T-cell lymphomas having a primary manifestation in the skin. [5] The disease's origin is a peripheral CD4+ T-lymphocyte, [3] although rarer CD8+/CD4- cases have been observed. [3]