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Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.
2 Treatment. 3 Prognosis. 4 ... Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in ... Common symptoms include fever, bone ...
Most cases are dealt with as supportive rather than curative because most therapies do not effectively increase survival. Indications for treatment include the presence of B symptoms, symptomatic organ involvement, increasing blood counts, hyperleukocytosis, leukostasis and/or worsening cytopenias. [6] [10]
Chronic myelogenous leukemia can be treated with relative safety at any time during pregnancy with Interferon-alpha hormones. [104] Treatment for chronic lymphocytic leukemias, which are rare in pregnant women, can often be postponed until after the end of the pregnancy.
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation , t(9;22)(q34;q11), of genetic material between chromosome 9 and ...
In aCML many clinical features (splenomegaly, myeloid predominance in the bone marrow with some dysplastic features but without a differentiation block) and laboratory abnormalities (myeloid proliferation, low leukocyte alkaline phosphatase values) suggest the diagnosis of chronic myelogenous leukemia (CML).
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Chronic myelogenous leukemia Chronic lymphocytic leukemia , including Hairy cell leukemia Myeloproliferative neoplasms including polycythemia vera , essential thrombocythemia , primary myelofibrosis , chronic neutrophilic leukemia , and chronic eosinophilic leukemia .
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