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The human ETV6 protein is a member of the ETS transcription factor family; however, it more often acts to inhibit than stimulate transcription of its target genes.ETV6 protein contains 3 domains: a) the pointed N-terminal (i.e. PNT) domain which forms oligomer partners with itself as well as other transcription factors (e.g. FLI1) and is required for ETV6's transcriptional repressing activity ...
The fusion gene product, ETV6-NTRK3, encodes a chimeric mutant protein, termed ETV6-NTRK3. [6] This fusion protein and its encoding ETV6-NTRK3 fusion gene are detected in the tumor cells of most (e.g. 88.6% [13] to 100% [8]) cases of MSC. The NTRK3 portion of ETV6-NTRK3 protein has up-regulated tyrosine kinase activity.
Crizotinib has proven useful in treating certain cases of acute lymphoblastic leukemia that are associated with the ETV6-NTRK3 fusion gene while larotrectinib and entrectinib have been useful in treating various cancers (e.g. a metastatic sarcoma, papillary thyroid cancer, non-small-cell lung carcinoma, gastrointestinal stromal tumor, mammary ...
Mammary analogue secretory carcinoma (MASC), also termed MASC SG, (the "SG" subscript indicates salivary gland) is a salivary gland neoplasm.It is a secretory carcinoma which shares the microscopic pathologic features with other types of secretory carcinomas including mammary secretory carcinoma, secretory carcinoma of the skin, and salivary gland–type carcinoma of the thyroid. [1]
Multiple ETS factors have been found to be associated with cancer, such as through gene fusion. For example, the ERG ETS transcription factor is fused to the EWS gene, resulting in a condition called Ewing's sarcoma. [6] The fusion of TEL to the JAK2 protein results in early pre-B acute lymphoid leukaemia. [7]
In 2002, findings from the WHI were released suggesting that women on HRT had greater risks of heart disease, stroke, dementia, and, scariest of all, breast cancer; as a result, millions of women ...
What I thought was testicular cancer was an inguinal hernia from doing deadlifts. ... Ph.D. “Many of the symptoms may express somatically, in the form of medical problems or conditions, such as ...
Signs and symptoms are not mutually exclusive, for example a subjective feeling of fever can be noted as sign by using a thermometer that registers a high reading. [7] Because many symptoms of cancer are gradual in onset and general in nature, cancer screening (also called cancer surveillance) is a key public health priority. This may include ...