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  2. Comparative genomics - Wikipedia

    en.wikipedia.org/wiki/Comparative_genomics

    Paralogous sequences are separated by gene cloning (gene duplication): if a particular gene in the genome is copied, then the copy of the two sequences is paralogous to the original gene. A pair of orthologous sequences is called orthologous pairs (orthologs), a pair of paralogous sequence is called collateral pairs (paralogs).

  3. Protein structure prediction - Wikipedia

    en.wikipedia.org/wiki/Protein_structure_prediction

    The pattern includes a series of possible matches at each position in the represented sequences, but there are not any inserted or deleted positions in the pattern or in the sequences. By way of contrast, sequence profiles are a type of scoring matrix that represents a similar set of patterns that includes insertions and deletions. Class

  4. Repeated sequence (DNA) - Wikipedia

    en.wikipedia.org/wiki/Repeated_sequence_(DNA)

    Repeated sequences (also known as repetitive elements, repeating units or repeats) are short or long patterns that occur in multiple copies throughout the genome. In many organisms, a significant fraction of the genomic DNA is repetitive, with over two-thirds of the sequence consisting of repetitive elements in humans. [ 1 ]

  5. Protein primary structure - Wikipedia

    en.wikipedia.org/wiki/Protein_primary_structure

    Protein sequence is typically notated as a string of letters, listing the amino acids starting at the amino-terminal end through to the carboxyl-terminal end. Either a three letter code or single letter code can be used to represent the 22 naturally encoded amino acids, as well as mixtures or ambiguous amino acids (similar to nucleic acid ...

  6. Central dogma of molecular biology - Wikipedia

    en.wikipedia.org/wiki/Central_dogma_of_molecular...

    The sequence of their monomers effectively encodes information. The transfers of information from one molecule to another are faithful, deterministic transfers, wherein one biopolymer's sequence is used as a template for the construction of another biopolymer with a sequence that is entirely dependent on the original biopolymer's sequence. When ...

  7. Quantitative structure–activity relationship - Wikipedia

    en.wikipedia.org/wiki/Quantitative_structure...

    The basic assumption for all molecule-based hypotheses is that similar molecules have similar activities. This principle is also called Structure–Activity Relationship ( SAR ). The underlying problem is therefore how to define a small difference on a molecular level, since each kind of activity, e.g. reaction ability, biotransformation ...

  8. DNA methylation - Wikipedia

    en.wikipedia.org/wiki/DNA_methylation

    The patterns of methylation also differ between cytosine sequence contexts; universally, CpG methylation is higher than CHG and CHH methylation, and CpG methylation can be found in both active genes and transposable elements, while CHG and CHH are usually relegated to silenced transposable elements. [80] [76]

  9. Gene regulatory network - Wikipedia

    en.wikipedia.org/wiki/Gene_regulatory_network

    Structure of a gene regulatory network Control process of a gene regulatory network. A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell.

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