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Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky (1858–1940), a Russian physician who trained and worked in the Russian Empire. The sign is present when slight rubbing of the skin results in exfoliation of the outermost layer.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion.
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[2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
1. Go Hear a Local Band. It's amazing the talent that goes undiscovered, and they might be in your local pub. 2. Visit a Farmer's Market. This might be seasonal in your area, but it's becoming ...
Carl the Collector was first announced on November 2023 as the first PBS Kids series to be led by an autistic character. [14] Targeted toward children ages 4–8, [4] Carl the Collector premiered on November 14, 2024, on PBS Kids. [15] The series' premiere in Canada and second season have not been announced.
Dougal Waters/Getty Images. Sidelines is a high-risk pregnancy support group in which volunteers lend an ear to women who are experiencing complicated pregnancies.