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Loren Pickart (1938-2023) isolated the copper peptide GHK-Cu from human plasma albumin in 1973. [5] It was noticed that liver tissue obtained from patients aged 60 to 80 years had an increased level of fibrinogen. However, when liver cells from old patients were incubated in the blood from the younger group, the older cells started functioning ...
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Chronic copper poisoning leading to liver failure was reported in a young adult male with no known genetic susceptibility who consumed 30–60 mg/d of copper as a mineral supplement for 3 years. [104] Individuals residing in U.S. households supplied with tap water containing >3 mg/L of copper exhibited no adverse health effects. [105]
In the case of copper the adult UL is set at 10 mg/day. [4] Copper gluconate is sold as a dietary supplement to provide copper. The typical dose is 2.0 mg copper per day. This is one-fifth what the IOM considers a safe upper limit. Long-term intake at amounts higher than the UL may cause liver damage. [4]
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