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The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Green Tobacco Sickness is characterized by a wide range of symptoms, including nausea, vomiting, headache, dizziness, and severe weakness. [4] These symptoms may be accompanied by fluctuations in blood pressure or heart rate. Abdominal cramping, chills, increased sweating, salivation and difficulty breathing are also common. [5]
The initial symptoms of nicotine poisoning may include rapid heart rate, sweating, feeling sick, and throwing up, and delayed symptoms include low blood pressure, seizures, and hypoventilation. [120] Rare serious effects included coma, seizure, trouble breathing, and heart attack. [121]
The nicotine patch can also cause strange dreams if worn while asleep. [20] Nasal sprays commonly cause nasal irritation, watering eyes, and coughing. [31] Serious risks include nicotine poisoning, which includes symptoms like visual disturbances, hyper-salivation, nausea, and vomiting; and continued addiction to nicotine products. [1]
Nicotine has been shown to produce birth defects in humans and is considered a teratogen. [42] [43] The median lethal dose of nicotine in humans is unknown. [44] High doses are known to cause nicotine poisoning, organ failure, and death through paralysis of respiratory muscles, [41] [45] though serious or fatal overdoses are rare. [46]
These symptoms can include cravings for nicotine, anger, irritability, anxiety, depression, impatience, trouble sleeping, restlessness, hunger, weight gain, and difficulty concentrating. [61] When trying to quit smoking with vaping a base containing nicotine, symptoms of withdrawal can include irritability, restlessness, poor concentration ...
A National Institute on Drug Abuse video entitled Anyone Can Become Addicted to Drugs. [21]Nicotine dependence is defined as a neurobiological adaptation to repeated drug exposure that is manifested by highly controlled or compulsive use, the development of tolerance, experiencing withdrawal symptoms upon cessation including cravings, and an inability to quit despite harmful effects. [9]
Vaping-associated pulmonary injury (VAPI), [4] also known as vaping-associated lung injury (VALI) [1] or e-cigarette, or vaping, product use associated lung injury (E/VALI), [2] [a] is an umbrella term, [15] [16] used to describe lung diseases associated with the use of vaping products that can be severe and life-threatening. [3]