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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.
The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [ 3 ] [ 14 ] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [ 15 ]
The ATLAS ACS 2 TIMI 51 trial for secondary prevention of major cardiovascular events in patients with acute coronary syndrome shows for the 2.5-mg twice-daily dose of rivaroxaban a reduction in overall (Absolute Risk Decrease 1,6%) and cardiovascular mortality vs placebo, despite an increased risk of TIMI (thrombolysis in myocardial infarction ...
Andexanet alfa is a biologic agent, a recombinant modified version of human activated factor X (FXa). [17] Andexanet alfa differs from native FXa due to the removal of a 34 residue fragment that contains the Gla domain. This modification reduces andexanet alfa's anticoagulant potential.
Medical Wikipedia is a mobile app which provides offline access to health information on Wikipedia.It is an instance of the Wikipedia arm of Kiwix.. On June 10th, 2015 Wiki Project Med Foundation and Wikimedia Switzerland launched an android app that contains all of the English Wikipedia's health care content: including medical, anatomy, medication, and sanitation related articles as tagged by ...
The following other wikis use this file: Usage on ar.wikipedia.org ريفاروكسابان; Usage on azb.wikipedia.org ریواروکسابان
Download QR code; In other projects ... English: Chemical formula of rivaroxaban (original brand name Xarelto, ... Usage on nl.wikipedia.org Rivaroxaban;