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The critical functional groups of rifampicin in its inhibitory binding of bacterial RNA polymerase are the four critical hydroxyl groups of the ansa bridge and the naphthol ring, which form hydrogen bonds with amino acid residues on the protein. [40] Rifampicin is the 3-(4-methyl-1-piperazinyl)-iminomethyl derivative of rifamycin SV. [41]
The rifamycin group includes the classic rifamycin drugs as well as the rifamycin derivatives rifampicin (or rifampin), rifabutin, rifapentine, rifalazil and rifaximin. Rifamycin, sold under the trade name Aemcolo, is approved in the United States for treatment of travelers' diarrhea in some circumstances. [1] [2] [3]
In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula −OH and composed of one oxygen atom covalently bonded to one hydrogen atom. In organic chemistry , alcohols and carboxylic acids contain one or more hydroxy groups.
Skeletal formula of tetracycline with atoms and four rings numbered and labeled.. Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. [1]
Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. [4] It is also used to both treat and prevent pneumocystis pneumonia (PCP). [4] [10] It is also used for toxoplasmosis in people unable to tolerate trimethoprim with sulfamethoxazole. [10]
A medical advocacy group on Tuesday sued the main U.S. health agencies over the sudden removal of websites containing public health information in response to an executive order by President ...
Giorgi Gakharia, a former prime minister of Georgia who now leads one of the country's main opposition groups, was hospitalised after being severely beaten late on Tuesday, a spokeswoman for his ...
It was initially proposed that the stabilization was due to water molecules forming a hydrogen bonding network linking the prolyl hydroxyl groups and the main-chain carbonyl groups. [6] It was subsequently shown that the increase in stability is primarily through stereoelectronic effects and that hydration of the hydroxyproline residues ...