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Sp100 nuclear antigen is an interferon stimulated antigen found in the cell nuclei of many human and higher animal cells. Autoantibodies directed against Sp100 are often found in patients with primary biliary cirrhosis. [1] Histologically Sp100 'dots' regions of the cell nucleus. Viral infection and mitogens affect the expression of the Sp100 ...
Anti-sp100 antibodies are found in association with primary biliary cirrhosis. [1] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30% of patients with primary biliary cirrhosis have sp100 Abs.
That nuclear bodies co-isolated with the nuclear matrix, and were linked to the fibrogranular nuclear matrix component by projections from the surface of the nuclear bodies. [11] The primary components of the nuclear dots are the proteins sp100 nuclear antigen, LYSP100(a homolog of sp100), [ 12 ] ISG20 , [ 13 ] PML antigen , NDP55 and 53kDa ...
Sp100 nuclear antigen; T. Tissue transglutaminase; Transglutaminase This page was last edited on 19 September 2016, at 16:21 (UTC). Text is available under the ...
Anti-sp100 antibodies [6] Sp100 nuclear antigen: Anti-glycoprotein-210 antibodies [7] nucleoporin 210kDa: Anti-transglutaminase antibodies: Anti-tTG: celiac disease: Anti-eTG: dermatitis herpetiformis: Anti-ganglioside antibodies: ganglioside GQ1B: Miller Fisher syndrome: ganglioside GD3: acute motor axonal neuropathy (AMAN) ganglioside GM1
Nuclear dot patterns show between 13 and 25 nuclear dots in interphase cells and are produced by anti-sp100 antibodies. Pleomorphic pattern is caused by antibodies to the proliferating cell nuclear antigen. [26] [53] [57] [58] Indirect immunofluorescence has been shown to be slightly superior compared to ELISA in detection of ANA from HEp-2 ...
An extractable nuclear antigen panel, or an ENA panel, tests for presence of autoantibodies in the blood that react with proteins in the cell nucleus.It is usually done as a follow-up to a positive antinuclear antibody test and when one is showing symptoms of an autoimmune disorder.
The gene, NUP210, encodes the nuclear pore (nuclear porin) glycoprotein-210 that is a major component of the human nuclear pore complex. References This ...