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In physiology, respiration is the transport of oxygen from the outside environment to the cells within tissues, and the removal of carbon dioxide in the opposite direction to the environment by a respiratory system. [1]
The carbon dioxide molecules form a carbamate with the four terminal-amine groups of the four protein chains in the deoxy form of the molecule. Thus, one hemoglobin molecule can transport four carbon dioxide molecules back to the lungs, where they are released when the molecule changes back to the oxyhemoglobin form. [6]
Carbon dioxide (CO 2) is produced in tissues as a byproduct of normal aerobic metabolism.It dissolves in the solution of blood plasma and into red blood cells (RBC), where carbonic anhydrase catalyzes its hydration to carbonic acid (H 2 CO 3).
In addition to enhancing removal of carbon dioxide from oxygen-consuming tissues, the Haldane effect promotes dissociation of carbon dioxide from hemoglobin in the presence of oxygen. In the oxygen-rich capillaries of the lung, this property causes the displacement of carbon dioxide to plasma as low-oxygen blood enters the alveolus and is vital ...
From the complete oxidation of one glucose molecule to carbon dioxide and oxidation of all the reduced coenzymes. Although there is a theoretical yield of 38 ATP molecules per glucose during cellular respiration, such conditions are generally not realized because of losses such as the cost of moving pyruvate (from glycolysis), phosphate, and ...
The decreased binding to carbon dioxide in the blood due to increased oxygen levels is known as the Haldane effect, and is important in the transport of carbon dioxide from the tissues to the lungs. A rise in the partial pressure of CO 2 or a lower pH will cause offloading of oxygen from hemoglobin, which is known as the Bohr effect .
The sum of these partial pressures (water, oxygen, carbon dioxide and nitrogen) comes to roughly 900 mbar (675 mmHg), which is some 113 mbar (85 mmHg) less than the total pressure of the respiratory gas. This is a significant saturation deficit, and it provides a buffer against supersaturation and a driving force for dissolving bubbles. [26]
In mammalian physiology, transport of carbon dioxide to the lungs involves a carbonation reaction catalyzed by the enzyme carbonic anhydrase. In the absence of such catalysts, carbon dioxide cannot be expelled sufficient rate to support metabolic needs. The enzyme harbors a zinc aquo complex, which captures carbon dioxide to give a zinc ...