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Sacrificial pseudoreplication (Figure 5b in Hurlbert 1984) occurs when means within a treatment are used in an analysis, and these means are tested over the within unit variance. In Figure 5b the erroneous F-ratio will have 1 df in the numerator (treatment) mean square and 4 df in the denominator mean square(2-1 = 1 df for each experimental unit).
This single cell shows the process of the central dogma of molecular biology, which are all steps researchers are interested to quantify (DNA, RNA, and Protein).. In cell biology, single-cell analysis and subcellular analysis [1] refer to the study of genomics, transcriptomics, proteomics, metabolomics, and cell–cell interactions at the level of an individual cell, as opposed to more ...
In cell biology, single-cell variability occurs when individual cells in an otherwise similar population differ in shape, size, position in the cell cycle, or molecular-level characteristics. Such differences can be detected using modern single-cell analysis techniques. [ 1 ]
Single-nucleotide polymorphisms (SNPs), which are a big part of genetic variation in the human genome, and copy number variation (CNV), pose problems in single cell sequencing, as well as the limited amount of DNA extracted from a single cell. Due to scant amounts of DNA, accurate analysis of DNA poses problems even after amplification since ...
[15] [16] [17] With the advance in single-cell technologies, newer approaches started to incorporate references for cell-types measured on a single-cell resolution obtained for a subset of subjects in the study or external subjects from a similar biological condition. [18] [1] [19]
[93] [115] Publication bias is augmented by the pressure to publish and the author's own confirmation bias, [b] and is an inherent hazard in the field, requiring a certain degree of skepticism on the part of readers. [41] Publication bias leads to what psychologist Robert Rosenthal calls the "file drawer effect".
A persistent joke about orange cats is that they all share a single brain cell among them. Of course, this is not necessarily true, and there’s no reason that orange (also called “ginger ...
These tags are added before PCR amplification, and can be used to reduce errors and quantitative bias introduced by the amplification. Applications include analysis of unique cDNAs to avoid PCR biases in iCLIP, [1] variant calling in ctDNA, gene expression in single-cell RNA-seq (scRNA-seq) [2] [3] and haplotyping via linked reads ...