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Gabapentin, sold under the trade name Neurontin, is used to treat neuropathic pain in horses. It may be given orally or intravenously, although oral bioavailability is fairly poor (~16%), and it can produce sedation and increased drinking. [81] Gabapentin has been used for femoral neuropathy following surgery, [82] laminitis, and headshaking in ...
This sometimes leads to static laminitis, particularly if the animal is confined in a stall. [10] A notable example is the 2006 Kentucky Derby winner Barbaro. [11] Transport laminitis sometimes occurs in horses confined in a trailer or other transportation for long periods of time. Historically, the most extreme instances were of horses shipped ...
Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses. It is most commonly seen in older animals, [ 1 ] and is classically associated with the formation of a long, wavy coat ( hirsutism ) and chronic laminitis .
Additionally, horses with a hind limb lameness will tend to reduce the degree of leg use. To do so, some horses will reduce the contraction time of the gluteals on the side of the lame leg, leading to a "hip roll" or "hip dip" and appearance that the hip drops a greater degree on the side of the lame leg. [10]
pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID) phenylpropanolamine – controls urinary incontinence in dogs
The oral bioavailability of gabapentin enacarbil (as gabapentin) is greater than or equal to 68%, across all doses assessed (up to 2,800 mg), with a mean of approximately 75%. [ 28 ] [ 1 ] In contrast to the other gabapentinoids, the pharmacokinetics of phenibut have been little-studied, and its oral bioavailability is unknown. [ 31 ]
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